Syllabus-4th edition

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Syllabus-4th edition

Posted by Terese Wignot, 1/6/06 at 2:09:55 PM. Instructor: Terese M. Wignot, Ph.D.
Office: SLC 267 Extension 4627 wignot@wilkes.edu
Office Hours: Please see: Wignot's Spring 2009 Weekly Schedule
Class Hours: Tues, Thurs 9:20-11:00
Location: Breiseth 107

Required Text: Horton, Moran, Scrimgeour, Perry, and Rawn; Principles of Biochemistry, 4th edition. Upper Saddle River, NJ: Prentice Hall Publishing,2006.

Course Objective: This course is designed as a one-semester overview of biochemistry. It will introduce the student to basic biochemical concepts. The emphasis of the course in the first half of the semester is to correlate the chemical structure of vitamins, proteins, carbohydrates and lipids to their biological and biochemical function. The emphasis will then shift to an understanding of bioenergetics and the major catabolic pathways. The catabolism of carbohydrates and fats will be discussed emphasizing reactions and pathway regulation. The last 45 minutes of the Thursday class will be dedicated to problem solving.

Grading: Suggested homework problems from each chapter of the text will be assigned. Additional homework will be collected or submitted on-line and graded. Three exams will be given as well as a comprehensive final exam. Homework, tests and the final will based on lecture material and homework problems. All exams are mandatory and no make-up exams will be given. Homework and tests may be web based. In case of illness, as demonstrated by a medical certificate and upon approval of the Dean, special arrangements will be made.

Plagiarism/Cheating. The Wilkes University community shares "a deep commitment to academic honest and integrity". Penalties for violation of the University plagiarism policy range from a zero on the assignment or test to course failure. Sufficiently egregious cases of plagiarism may be referred to the Student Affairs Cabinet for further disciplinary sanctions. The University recognizes the following as violations of Intellectual Responsibility plagiarism, cheating and collusion. Furthermore the University also recognizes various forms of plagiarism, deliberate, unintentional and self. Additional details can be found in the Student Handbook, p. 54-55.

Tentative Dates* Tentative %*

Homework Due 5

Tues Feb 10 Exam 1 Thurs Feb 12 20-25*

Tues Mar 17 Exam 2 Thurs Mar 19 20-25*

Tues April 21 Exam 3 Thurs April 23 20-25*

Final Set by Registrar 30

*- your highest exam score will be worth 25% the other two exams are worth 20%
Attendance is required under University policy. The withdraw policy of the University will be strictly enforced.

Percentage Grade

>90 4.0

85-89 3.5

80-84 3.0

75-79 2.5

70-74 2.0

65-69 1.5

60-64 1.0

<60 0

All tentative dates, point distributions and cut offs are subject to change at the discretion of the instructor.

*- the %s and dates are subject to change as the semester progresses at the discretion of the instructor.

COURSE OUTLINE

WEEK	TOPIC	CHAPTER	PROBLEMS
1	Introduction	1		Definitions, Macro & Micro Strctuctures, C,O,N cycles Cells
	Acids & Bases	2	1,2,8	Water as a solvent, Acids, Bases Power Point:Aqueous_water
2	Buffers	2	9,13,14,15	Buffers, Henderson-Hasselbach equation
	Amino Acids	3	5,7,8,9,10,13, 16,17	Structures, Classification, Titration, Peptide bonds (Exclude 3.6-3.9) Power Point:AminoAcids
3	Proteins	4	1,3	Structures, Folding(exclude 4.11-4.15) Power Point:Protein_structure,ribonuclease
	Enzymes	5		Classifications
4	Enzymes	5	2,5,6,8,15,16	Michaelis-Menton kinetics, Inhibition, Regulation
5	Homework & TEST	1-part of 5	all	Power Point:PHA_Enzymes
	Enzyme Mechanism	6	1,7,13,16	Mechanisms (exclude 6.4 -6.9)
6	Lipids & Membranes	9	7,11	Structures, Micells & bilayers, Fluid mosaic (exclude 9.6,9.7 &9.12) Power Point:lipids&membranes
7	Metabolism	10	1	Introduction to metabolism
	Bioenergetics	10	2,5,11	ATP, Gibbs free energy (exclude 11.9) Bioenergetics_ATP
8	Spring	Break	Enjoy
9	Vitamins as Coenzymes	7	1,2	Structures, Coenzyme forms and reactions Power Point:Coenzymes_vitamins
	Carbohydrates	8	8,9,11	Structure of aldoses and ketoses Power Point:CHO
10	Homework and TEST	5-8,9,10	all
11	Glycolysis	11	1,2,3,8	Reactions, Enzymes, Regulation
	Glycogen Metabolism	12	4,6,7	Reactions, Enzymes, Regulation glycogen_metabolism
12	Citric Acid Cycle	13	3,5,6,7	Degradation, Synthesis, Hormonal control (exclude13.4-13.10)PDH
	Review	10.12 A & B		cAMP mediated signalling
13	Bioenergetics	10.9	12,13,14,15	Redox, Free energy
	ETC	14	1,2,4,9,11	ECT, Proton motive force, inhibitor ElectronTransport
14	Catabolism of Fats	16	3,4	Structures, Reactions, Regulations (exclude 16.6-16.12)Lipid_Metabolism
	Catabolism of Amino Acids	17	11	Selected sections of chapter 17
15	Homework and TEST	10.9-14,16,17	all

EXTRA CREDIT: Extra credit will be assigned on a first come first serve basis for topics and dates. The projects will involve filling the display cases on the second floor by SLC 201, SLC 275 and SLC 261. The projects will be displayed for a week. It will be the student's responsibility to put up the display on Monday of the chosen week. The topic must come from a current scientific magazine or journal, correspond to a topic in the course, and must be approved by the instructor. The project must include at least four pages of written text and illustrations to fill the case. Appearance is important. The text can be distributed among the illustrations. Two references, other than your book, must be used and cited.No web references allowed. Each Monday of the semester is available starting the week of January 19 through Monday April 27 and there are three display cases available per week. You must sign up for a date and topic by February 29. Each student can receive 0 to 3 points added to their overall grade. A maximum of three students per extra credit project will be allowed.

Last update: Tuesday, April 21, 2009 at 8:41:02 AM.

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